Inhibition of CTGF ameliorates peritoneal fibrosis through suppression of fibroblast and myofibroblast accumulation and angiogenesis

Peritoneal fibrosis (PF) is a serious complication in various clinical settings, but the mechanisms driving it remain to be fully determined. Connective tissue growth factor (CTGF) is known to regulate fibroblast activities. We therefore examined if CTGF inhibition has anti-fibrotic effects in PF. P...

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Udgivet i:Sci Rep
Main Authors: Sakai, Norihiko, Nakamura, Miki, Lipson, Kenneth E., Miyake, Taito, Kamikawa, Yasutaka, Sagara, Akihiro, Shinozaki, Yasuyuki, Kitajima, Shinji, Toyama, Tadashi, Hara, Akinori, Iwata, Yasunori, Shimizu, Miho, Furuichi, Kengo, Kaneko, Shuichi, Tager, Andrew M., Wada, Takashi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5511333/
https://ncbi.nlm.nih.gov/pubmed/28710437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05624-2
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