Genetic deletion or pharmacologic antagonism of LPA(1) ameliorates dermal fibrosis in a scleroderma mouse model

OBJECTIVE: Scleroderma, or systemic sclerosis (SSc), is characterized by progressive multi-organ fibrosis. We recently implicated lysophosphatidic acid (LPA) in the pathogenesis of pulmonary fibrosis. Here we investigated the roles of LPA and two of its receptors, LPA(1) and LPA(2), in dermal fibros...

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Main Authors: Castelino, Flavia V., Seiders, Jon, Bain, Gretchen, Brooks, Sarah F., King, Chris, Swaney, James S., Lorrain, Daniel S., Chun, Jerold, Luster, Andrew D., Tager, Andrew M.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3086986/
https://ncbi.nlm.nih.gov/pubmed/21305523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.30262
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