An Autotaxin-LPA-IL-6 Amplification Loop Drives Scleroderma Fibrosis

OBJECTIVE: We previously implicated the lipid mediator lysophosphatidic acid (LPA) in dermal fibrosis in systemic sclerosis (SSc). Here we identify the role of the LPA-producing enzyme autotaxin (ATX), and connect the ATX-LPA and IL-6 pathways in SSc. METHODS: We evaluated a novel ATX inhibitor, PAT...

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Bibliografiske detaljer
Udgivet i:Arthritis Rheumatol
Main Authors: Castelino, Flavia V., Bain, Gretchen, Pace, Veronica A., Black, Katharine E., George, Leaya, Probst, Clemens K., Goulet, Lance, Lafyatis, Robert, Tager, Andrew M.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5125861/
https://ncbi.nlm.nih.gov/pubmed/27390295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.39797
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