Screening for YAP Inhibitors Identifies Statins as Modulators of Fibrosis

Idiopathic pulmonary fibrosis is a lung disease with limited therapeutic options that is characterized by pathological fibroblast activation and aberrant lung remodeling with scar formation. YAP (Yes-associated protein) is a transcriptional coactivator that mediates mechanical and biochemical signal...

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Bibliografske podrobnosti
izdano v:Am J Respir Cell Mol Biol
Main Authors: Santos, Daniela M., Pantano, Lorena, Pronzati, Gina, Grasberger, Paula, Probst, Clemens K., Black, Katharine E., Spinney, Jillian J., Hariri, Lida P., Nichols, Royale, Lin, Yufei, Bieler, Michael, Seither, Peter, Nicklin, Paul, Wyatt, David, Tager, Andrew M., Medoff, Benjamin D.
Format: Artigo
Jezik:Inglês
Izdano: American Thoracic Society 2020
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7110981/
https://ncbi.nlm.nih.gov/pubmed/31944822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2019-0296OC
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