Inactivation of hypoxia-induced YAP by statins overcomes hypoxic resistance tosorafenib in hepatocellular carcinoma cells

Sorafenib is a multikinase inhibitor used as a first-line treatment for advanced hepatocellular carcinoma (HCC), but it has shown modest to low response rates. The characteristic tumour hypoxia of advanced HCC maybe a major factor underlying hypoxia-mediated treatment failure. Thus, it is urgent to...

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Publicado no:Sci Rep
Main Authors: Zhou, Tian-yi, Zhuang, Lin-han, Hu, Yan, Zhou, Yu-lu, Lin, Wen-kai, Wang, Dan-dan, Wan, Zi-qian, Chang, Lin-lin, Chen, Ying, Ying, Mei-dan, Chen, Zi-bo, Ye, Song, Lou, Jian-shu, He, Qiao-jun, Zhu, Hong, Yang, Bo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967870/
https://ncbi.nlm.nih.gov/pubmed/27476430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30483
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