Treatment of AG129 mice with antisense morpholino oligomers increases survival time following challenge with dengue 2 virus

OBJECTIVES: To determine the antiviral activity of phosphorodiamidate morpholino oligomers (PMO) and peptide-conjugated PMO (PPMO) in AG129 mice infected with dengue 2 virus (DENV-2). METHODS: Antisense PMO and PPMO were designed against the 5′ terminal region (5′SL) or the 3′-cyclization sequence r...

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Bibliografiska uppgifter
I publikationen:J Antimicrob Chemother
Huvudupphovsmän: Stein, David A., Huang, Claire Y.-H., Silengo, Shawn, Amantana, Adams, Crumley, Stacy, Blouch, Robert E., Iversen, Patrick L., Kinney, Richard M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2008
Ämnen:
Original Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7109848/
https://ncbi.nlm.nih.gov/pubmed/18567576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkn221
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