Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation

Cystic fibrosis (CF) lung disease is characterized by an inflammatory response that can lead to terminal respiratory failure. The cystic fibrosis transmembrane conductance regulator (CFTR) is mutated in CF, and we hypothesized that dysfunctional CFTR in platelets, which are key participants in immun...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Ortiz-Muñoz, Guadalupe, Yu, Michelle A., Lefrançais, Emma, Mallavia, Beñat, Valet, Colin, Tian, Jennifer J., Ranucci, Serena, Wang, Kristin M., Liu, Zhe, Kwaan, Nicholas, Dawson, Diana, Kleinhenz, Mary Ellen, Khasawneh, Fadi T., Haggie, Peter M., Verkman, Alan S., Looney, Mark R.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7108932/
https://ncbi.nlm.nih.gov/pubmed/31961827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI129635
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