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An unstable transmembrane segment in the cystic fibrosis transmembrane conductance regulator.

The cystic fibrosis transmembrane conductance regulator (CFTR), a chloride channel with 12 membrane-spanning sequences, undergoes inefficient maturation in the endoplasmic reticulum (ER). Potentially charged residues in transmembrane segments may contribute to this defect in biogenesis. We demonstra...

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Bibliografiske detaljer
Main Authors: Tector, M, Hartl, F U
Format: Artigo
Sprog:Inglês
Udgivet: 1999
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171692/
https://ncbi.nlm.nih.gov/pubmed/10562541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.22.6290
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