Defective Innate Immunity and Hyperinflammation in Newborn Cystic Fibrosis Transmembrane Conductance Regulator–Knockout Ferret Lungs

Mucociliary clearance (MCC) and submucosal glands are major components of airway innate immunity that have impaired function in cystic fibrosis (CF). Although both of these defense systems develop postnatally in the ferret, the lungs of newborn ferrets remain sterile in the presence of a functioning...

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Detalhes bibliográficos
Publicado no:Am J Respir Cell Mol Biol
Main Authors: Keiser, Nicholas W., Birket, Susan E., Evans, Idil A., Tyler, Scott R., Crooke, Adrianne K., Sun, Xingshen, Zhou, Weihong, Nellis, Joseph R., Stroebele, Elizabeth K., Chu, Kengyeh K., Tearney, Guillermo J., Stevens, Mark J., Harris, J. Kirk, Rowe, Steven M., Engelhardt, John F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4491130/
https://ncbi.nlm.nih.gov/pubmed/25317669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2014-0250OC
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