Infection Is Not Required for Mucoinflammatory Lung Disease in CFTR-Knockout Ferrets

Rationale: Classical interpretation of cystic fibrosis (CF) lung disease pathogenesis suggests that infection initiates disease progression, leading to an exuberant inflammatory response, excessive mucus, and ultimately bronchiectasis. Although symptomatic antibiotic treatment controls lung infectio...

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Detalhes bibliográficos
Publicado no:Am J Respir Crit Care Med
Main Authors: Rosen, Bradley H., Evans, T. Idil Apak, Moll, Shashanna R., Gray, Jaimie S., Liang, Bo, Sun, Xingshen, Zhang, Yulong, Jensen-Cody, Chandler W., Swatek, Anthony M., Zhou, Weihong, He, Nan, Rotti, Pavana G., Tyler, Scott R., Keiser, Nicholas W., Anderson, Preston J., Brooks, Leonard, Li, Yalan, Pope, R. Marshall, Rajput, Maheen, Hoffman, Eric A., Wang, Kai, Harris, J. Kirk, Parekh, Kalpaj R., Gibson-Corley, Katherine N., Engelhardt, John F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2018
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5955060/
https://ncbi.nlm.nih.gov/pubmed/29327941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201708-1616OC
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