Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation

Cystic fibrosis (CF) lung disease is characterized by an inflammatory response that can lead to terminal respiratory failure. The cystic fibrosis transmembrane conductance regulator (CFTR) is mutated in CF, and we hypothesized that dysfunctional CFTR in platelets, which are key participants in immun...

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Bibliografski detalji
Izdano u:J Clin Invest
Glavni autori: Ortiz-Muñoz, Guadalupe, Yu, Michelle A., Lefrançais, Emma, Mallavia, Beñat, Valet, Colin, Tian, Jennifer J., Ranucci, Serena, Wang, Kristin M., Liu, Zhe, Kwaan, Nicholas, Dawson, Diana, Kleinhenz, Mary Ellen, Khasawneh, Fadi T., Haggie, Peter M., Verkman, Alan S., Looney, Mark R.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2020
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7108932/
https://ncbi.nlm.nih.gov/pubmed/31961827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI129635
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