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HIV-1 Protease Catalytic Efficiency Effects Caused by Random Single Amino Acid Substitutions

Protein evolution has occurred by successive fixation of individual mutations. The probability of fixation depends on the fitness of the mutation, and the arising variant can be deleterious, neutral, or beneficial. Despite its relevance, only few studies have estimated the distribution of fitness ef...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Biol Evol
Main Authors: Parera, Mariona, Fernàndez, Guerau, Clotet, Bonaventura, Martínez, Miguel Angel
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7107532/
https://ncbi.nlm.nih.gov/pubmed/17090696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msl168
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