Complexity and Catalytic Efficiency of Hepatitis C Virus (HCV) NS3 and NS4A Protease Quasispecies Influence Responsiveness to Treatment with Pegylated Interferon plus Ribavirin in HCV/HIV-Coinfected Patients

The role of the hepatitis C virus (HCV) NS3/4A protease in ablating the signaling pathway involved in the production of alpha/beta interferon (IFN-α/β) suggests a relationship between NS3/4A proteolytic activity and a patient's response to IFN-based therapy. To identify viral factors associated...

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Detalhes bibliográficos
Main Authors: Aparicio, Ester, Franco, Sandra, Parera, Mariona, Andrés, Cristina, Tural, Cristina, Clotet, Bonaventura, Martínez, Miguel Angel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Genetic Diversity and Evolution
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126303/
https://ncbi.nlm.nih.gov/pubmed/21471227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00308-11
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