Co-delivery of 2-Deoxyglucose and a Glutamine Metabolism Inhibitor V9302 via a Prodrug Micellar Formulation for Synergistic Targeting of Metabolism in Cancer

The unique metabolic demand of cancer cells suggests a new therapeutic strategy targeting the metabolism in cancers. V9302 is a recently reported inhibitor of ASCT2 amino acid transporter which shows promising antitumor activity by blocking glutamine uptake. However, its poor solubility in aqueous s...

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Publicat a:Acta Biomater
Autors principals: Luo, Zhangyi, Xu, Jieni, Sun, Jingjing, Huang, Haozhe, Zhang, Ziqian, Ma, Weina, Wan, Zhuoya, Liu, Yangwuyue, Pardeshi, Apurva, Li, Song
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7105957/
https://ncbi.nlm.nih.gov/pubmed/31958597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.actbio.2020.01.019
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