Metformin-conjugated micellar system with intratumoral pH responsive de-shielding for co-delivery of doxorubicin and nucleic acid

A novel PMet-P(cdmPEG(2K)) polymeric micellar carrier was developed for tumor-targeted co-delivery of DOX and nucleic acids (NA), based on polymetformin and a structure designed to lose the PEG shell in response to the acidic extracellular tumor environment. NA/DOX co-loaded micelleplexes exhibited...

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Publicat a:Biochem Pharmacol
Autors principals: Liu, Yanhua, Sun, Jingjing, Huang, Yixian, Chen, Yichao, Li, Jiang, Liang, Lei, Xu, Jieni, Wan, Zhuoya, Zhang, Bei, Li, Zuojun, Li, Song
Format: Artigo
Idioma:Inglês
Publicat: 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8187262/
https://ncbi.nlm.nih.gov/pubmed/33545119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2021.114453
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