CBMT-35. METABOLIC REWIRING BY ONC201/TIC10 AND 2-DEOXYGLUCOSE HAS SYNERGISTIC ANTI-GLIOBLASTOMA ACTIVITY

BACKGROUND: Metabolic dysregulation is a common feature of cancers such as primary brain malignancies. In this work we examined whether a rewiring of the metabolome by a multi-targeting approach would induce enhanced anti-neoplastic activity in glioblastoma. METHODS: Preclinical testing of a combine...

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Publicat a:Neuro Oncol
Autors principals: Pruss, Maximilian, Dwucet, Annika, Hlavac, Michal, Kast, Richard, Westhoff, Mike-Andrew, Wirtz, Rainer, Halatsch, Marc-Eric, Siegelin, Markus, Karpel-Massler, Georg
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Cell Biology and Metabolism
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847679/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.157
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