Dual metabolic reprogramming by ONC201/TIC10 and 2-Deoxyglucose induces energy depletion and synergistic anti-cancer activity in glioblastoma

BACKGROUND: Dysregulation of the metabolome is a hallmark of primary brain malignancies. In this work we examined whether metabolic reprogramming through a multi-targeting approach causes enhanced anti-cancer activity in glioblastoma. METHODS: Preclinical testing of a combined treatment with ONC201/...

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Библиографические подробности
Опубликовано в: :Br J Cancer
Главные авторы: Pruss, Maximilian, Dwucet, Annika, Tanriover, Mine, Hlavac, Michal, Kast, Richard Eric, Debatin, Klaus-Michael, Wirtz, Christian Rainer, Halatsch, Marc-Eric, Siegelin, Markus David, Westhoff, Mike-Andrew, Karpel-Massler, Georg
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7156767/
https://ncbi.nlm.nih.gov/pubmed/32115576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-020-0759-0
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