Co-delivery of 2-Deoxyglucose and a Glutamine Metabolism Inhibitor V9302 via a Prodrug Micellar Formulation for Synergistic Targeting of Metabolism in Cancer

The unique metabolic demand of cancer cells suggests a new therapeutic strategy targeting the metabolism in cancers. V9302 is a recently reported inhibitor of ASCT2 amino acid transporter which shows promising antitumor activity by blocking glutamine uptake. However, its poor solubility in aqueous s...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Acta Biomater
Hlavní autoři: Luo, Zhangyi, Xu, Jieni, Sun, Jingjing, Huang, Haozhe, Zhang, Ziqian, Ma, Weina, Wan, Zhuoya, Liu, Yangwuyue, Pardeshi, Apurva, Li, Song
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7105957/
https://ncbi.nlm.nih.gov/pubmed/31958597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.actbio.2020.01.019
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky