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Active transport of rhodamine 123 by the human multidrug transporter P‐glycoprotein involves two independent outer gates

Human P‐glycoprotein (P‐gp) is a multispecific drug‐efflux transporter, which plays an important role in drug resistance and drug disposition. Recent cryo‐electron microscopy structures confirmed its rotationally symmetric architecture, which allows dual interaction with ATP and substrates. We here...

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Dades bibliogràfiques
Publicat a:Pharmacol Res Perspect
Autors principals: Nasim, Fauzia, Schmid, Diethart, Szakács, Gergely, Sohail, Azmat, Sitte, Harald H., Chiba, Peter, Stockner, Thomas
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7105846/
https://ncbi.nlm.nih.gov/pubmed/32232949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.572
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