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Active transport of rhodamine 123 by the human multidrug transporter P‐glycoprotein involves two independent outer gates
Human P‐glycoprotein (P‐gp) is a multispecific drug‐efflux transporter, which plays an important role in drug resistance and drug disposition. Recent cryo‐electron microscopy structures confirmed its rotationally symmetric architecture, which allows dual interaction with ATP and substrates. We here...
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| Veröffentlicht in: | Pharmacol Res Perspect |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley and Sons Inc.
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7105846/ https://ncbi.nlm.nih.gov/pubmed/32232949 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.572 |
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