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Active transport of rhodamine 123 by the human multidrug transporter P‐glycoprotein involves two independent outer gates

Human P‐glycoprotein (P‐gp) is a multispecific drug‐efflux transporter, which plays an important role in drug resistance and drug disposition. Recent cryo‐electron microscopy structures confirmed its rotationally symmetric architecture, which allows dual interaction with ATP and substrates. We here...

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Bibliografische gegevens
Gepubliceerd in:Pharmacol Res Perspect
Hoofdauteurs: Nasim, Fauzia, Schmid, Diethart, Szakács, Gergely, Sohail, Azmat, Sitte, Harald H., Chiba, Peter, Stockner, Thomas
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7105846/
https://ncbi.nlm.nih.gov/pubmed/32232949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.572
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