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Molecular Mechanism of Taurocholate Transport by the Bile Salt Export Pump, an ABC Transporter Associated with Intrahepatic CholestasisS

The bile salt export pump (BSEP/ABCB11) transports bile salts nucleotide binding site 1) by glutamate imparted hydrolysis from hepatocytes into bile canaliculi. Its malfunction is associ-competency to this site. Importantly, this mutation was able to ated with severe liver disease. One reason for fu...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Mol Pharmacol
Main Authors: Sohail, Muhammad Imran, Schmid, Diethart, Wlcek, Katrin, Spork, Matthias, Szakács, Gergely, Trauner, Michael, Stockner, Thomas, Chiba, Peter
פורמט: Artigo
שפה:Inglês
יצא לאור: 2017
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610612/
https://ncbi.nlm.nih.gov/pubmed/28784620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.117.108688
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