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Active transport of rhodamine 123 by the human multidrug transporter P‐glycoprotein involves two independent outer gates
Human P‐glycoprotein (P‐gp) is a multispecific drug‐efflux transporter, which plays an important role in drug resistance and drug disposition. Recent cryo‐electron microscopy structures confirmed its rotationally symmetric architecture, which allows dual interaction with ATP and substrates. We here...
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| Publicado no: | Pharmacol Res Perspect |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7105846/ https://ncbi.nlm.nih.gov/pubmed/32232949 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.572 |
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