SENP1 regulates IFN-γ−STAT1 signaling through STAT3−SOCS3 negative feedback loop

Interferon-γ (IFN-γ) triggers macrophage for inflammation response by activating the intracellular JAK−STAT1 signaling. Suppressor of cytokine signaling 1 (SOCS1) and protein tyrosine phosphatases can negatively modulate IFN-γ signaling. Here, we identify a novel negative feedback loop mediated by S...

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Udgivet i:J Mol Cell Biol
Main Authors: Yu, Tingting, Zuo, Yong, Cai, Rong, Huang, Xian, Wu, Shuai, Zhang, Chenxi, Chin, Y Eugene, Li, Dongdong, Zhang, Zhenning, Xia, Nansong, Wang, Qi, Shen, Hao, Yao, Xuebiao, Zhang, Zhong-Yin, Xue, Song, Shen, Lei, Cheng, Jinke
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2017
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7104919/
https://ncbi.nlm.nih.gov/pubmed/27702761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjw042
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