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SENP1 Is a Crucial Regulator for Cell Senescence through DeSUMOylation of Bmi1
Cell senescence can limit proliferative potential and prevent tumorigenesis. Bmi1 is a key regulator in cell senescence by suppressing the Ink4a/Arf locus. However, how to regulate Bmi1 activity in cell senescence is largely unknown. Here, we show that SENP1 plays an important role in cell senescenc...
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| Veröffentlicht in: | Sci Rep |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5034316/ https://ncbi.nlm.nih.gov/pubmed/27659494 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34099 |
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