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ERK is a negative feedback regulator for IFN-γ/STAT1 signaling by promoting STAT1 ubiquitination

BACKGROUND: We recently reported that STAT1 plays a tumor suppressor role, and ERK was inversely correlation with STAT1 expression in esophageal squamous cell carcinoma (ESCC). Here, we investigated the mechanism(s) that are responsible for the ERK regulates STAT1 in ESCC. METHODS: We performed the...

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Bibliografiske detaljer
Udgivet i:BMC Cancer
Main Authors: Zhang, Ying, Chen, Yelong, Liu, Zhaoyong, Lai, Raymond
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5984314/
https://ncbi.nlm.nih.gov/pubmed/29855346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4539-7
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