Modulation of CRMP2 via (S)-Lacosamide shows therapeutic promise but is ultimately ineffective in a mouse model of CLN6-Batten disease

CLN6-Batten disease is a rare neurodegenerative disorder with no cure, characterized by accumulation of lipofuscin in the lysosome, glial activation, and neuronal death. Here we test the therapeutic efficacy of modulating collapsin response mediator protein 2 (CRMP2) activity via S-N-benzy-2-acetami...

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Detalhes bibliográficos
Publicado no:Neuronal Signal
Main Authors: White, Katherine A., Cain, Jacob T., Magee, Helen, Yeon, Seul Ki, Park, Ki Duk, Khanna, Rajesh, Weimer, Jill M.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2019
Assuntos:
Translational Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7104323/
https://ncbi.nlm.nih.gov/pubmed/32269836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/NS20190001
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