CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide

Neurofibromatosis type 1 (NF1) is a rare autosomal dominant disease linked to mutations of the Nf1 gene. Patients with NF1 commonly experience severe pain. Studies on mice with Nf1 haploinsufficiency have been instructive in identifying sensitization of ion channels as a possible cause underlying th...

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Veröffentlicht in:Pain
Hauptverfasser: Moutal, Aubin, Yang, Xiaofang, Li, Wennan, Gilbraith, Kerry B., Luo, Shizhen, Cai, Song, François-Moutal, Liberty, Chew, Lindsey A., Yeon, Seul Ki, Bellampalli, Shreya S., Qu, Chaoling, Xie, Jennifer Y., Ibrahim, Mohab M., Khanna, May, Park, Ki Duk, Porreca, Frank, Khanna, Rajesh
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6362827/
https://ncbi.nlm.nih.gov/pubmed/28809766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/j.pain.0000000000001002
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