CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide

Neurofibromatosis type 1 (NF1) is a rare autosomal dominant disease linked to mutations of the Nf1 gene. Patients with NF1 commonly experience severe pain. Studies on mice with Nf1 haploinsufficiency have been instructive in identifying sensitization of ion channels as a possible cause underlying th...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Pain
Päätekijät: Moutal, Aubin, Yang, Xiaofang, Li, Wennan, Gilbraith, Kerry B., Luo, Shizhen, Cai, Song, François-Moutal, Liberty, Chew, Lindsey A., Yeon, Seul Ki, Bellampalli, Shreya S., Qu, Chaoling, Xie, Jennifer Y., Ibrahim, Mohab M., Khanna, May, Park, Ki Duk, Porreca, Frank, Khanna, Rajesh
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6362827/
https://ncbi.nlm.nih.gov/pubmed/28809766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/j.pain.0000000000001002
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