The functionalized amino acid (S)-Lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowth

Activity-dependent neurite outgrowth is a highly complex, regulated process with important implications for neuronal circuit remodeling in development as well as in seizure-induced sprouting in epilepsy. Recent work has linked outgrowth to collapsin response mediator protein 2 (CRMP2), an intracellu...

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Bibliographic Details
Main Authors: Wilson, Sarah M., Moutal, Aubin, Melemedjian, Ohannes K., Wang, Yuying, Ju, Weina, François-Moutal, Liberty, Khanna, May, Khanna, Rajesh
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2014
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109617/
https://ncbi.nlm.nih.gov/pubmed/25104922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2014.00196
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