A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors

Targeting proteins within the N-type voltage-gated calcium channel (CaV2.2) complex has proven to be an effective strategy for developing novel pain therapeutics. We describe a novel peptide aptamer derived from the collapsin response mediator protein 2 (CRMP2), a CaV2.2-regulatory protein. Addition...

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Bibliografske podrobnosti
izdano v:Pain
Main Authors: François-Moutal, Liberty, Wang, Yue, Moutal, Aubin, Cottier, Karissa E., Melemedjian, Ohannes K., Yang, Xiaofang, Wang, Yuying, Ju, Weina, Largent-Milnes, Tally M., Khanna, May, Vanderah, Todd W., Khanna, Rajesh
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766324/
https://ncbi.nlm.nih.gov/pubmed/25782368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/j.pain.0000000000000147
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