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Specific binding of lacosamide to collapsin response mediator protein 2 (CRMP2) and direct impairment of its canonical function: implications for the therapeutic potential of lacosamide
The novel anti-epileptic drug lacosamide (LCM; SPM927, Vimpat(®)) has been heralded as having a dual-mode of action through interactions with both the voltage-gated sodium channel and the neurite outgrowth-promoting collapsin response mediator protein 2 (CRMP2). Lacosamide’s ability to dampen neuron...
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| Pubblicato in: | Mol Neurobiol |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4272652/ https://ncbi.nlm.nih.gov/pubmed/24944082 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-014-8775-9 |
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