Modulation of CRMP2 via (S)-Lacosamide shows therapeutic promise but is ultimately ineffective in a mouse model of CLN6-Batten disease

CLN6-Batten disease is a rare neurodegenerative disorder with no cure, characterized by accumulation of lipofuscin in the lysosome, glial activation, and neuronal death. Here we test the therapeutic efficacy of modulating collapsin response mediator protein 2 (CRMP2) activity via S-N-benzy-2-acetami...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Neuronal Signal
मुख्य लेखकों: White, Katherine A., Cain, Jacob T., Magee, Helen, Yeon, Seul Ki, Park, Ki Duk, Khanna, Rajesh, Weimer, Jill M.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Portland Press Ltd. 2019
विषय:
Translational Science
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC7104323/
https://ncbi.nlm.nih.gov/pubmed/32269836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/NS20190001
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