Modulation of CRMP2 via (S)-Lacosamide shows therapeutic promise but is ultimately ineffective in a mouse model of CLN6-Batten disease

CLN6-Batten disease is a rare neurodegenerative disorder with no cure, characterized by accumulation of lipofuscin in the lysosome, glial activation, and neuronal death. Here we test the therapeutic efficacy of modulating collapsin response mediator protein 2 (CRMP2) activity via S-N-benzy-2-acetami...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Neuronal Signal
Egile Nagusiak: White, Katherine A., Cain, Jacob T., Magee, Helen, Yeon, Seul Ki, Park, Ki Duk, Khanna, Rajesh, Weimer, Jill M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Portland Press Ltd. 2019
Gaiak:
Translational Science
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7104323/
https://ncbi.nlm.nih.gov/pubmed/32269836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/NS20190001
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