Metalloproteinase PAPP-A regulation of IGF-1 contributes to polycystic kidney disease pathogenesis

Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic cause of end-stage renal disease (ESRD). The treatment options for ADPKD are limited. We observed an upregulation in several IGF-1 pathway genes in the kidney of Pkd1(RC/RC) mice, a model of ADPKD. Pregnancy-associated p...

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Vydáno v:JCI Insight
Hlavní autoři: Kashyap, Sonu, Hein, Kyaw Zaw, Chini, Claudia C.S., Lika, Jorgo, Warner, Gina M., Bale, Laurie K., Torres, Vicente E., Harris, Peter C., Oxvig, Claus, Conover, Cheryl A., Chini, Eduardo N.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7101148/
https://ncbi.nlm.nih.gov/pubmed/31990681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.135700
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