The Effect of 4-Methylpyrazole on Oxidative Metabolism of Acetaminophen in Human Volunteers

INTRODUCTION: Acetaminophen (APAP) is commonly ingested in both accidental and suicidal overdose. Oxidative metabolism by cytochrome P450 2E1 (CYP2E1) produces the hepatotoxic metabolite, N-acetyl-p-benzoquinone imine. CYP2E1 inhibition using 4-methylpyrazole (4-MP) has been shown to prevent APAP-in...

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Udgivet i:J Med Toxicol
Main Authors: Kang, A. Min, Padilla-Jones, Angela, Fisher, Erik S., Akakpo, Jephte Y., Jaeschke, Hartmut, Rumack, Barry H., Gerkin, Richard D., Curry, Steven C.
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2019
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7099124/
https://ncbi.nlm.nih.gov/pubmed/31768936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13181-019-00740-z
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