Reduced In Vitro Susceptibility of Streptococcus pyogenes to β-Lactam Antibiotics Associated with Mutations in the pbp2x Gene Is Geographically Widespread

Recently, two related Streptococcus pyogenes strains with reduced susceptibility to ampicillin, amoxicillin, and cefotaxime, antibiotics commonly used to treat S. pyogenes infections, were reported. The two strains had the same nonsynonymous (amino acid-substituting) mutation in the pbp2x gene, enco...

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Dettagli Bibliografici
Pubblicato in:J Clin Microbiol
Autori principali: Musser, James M., Beres, Stephen B., Zhu, Luchang, Olsen, Randall J., Vuopio, Jaana, Hyyryläinen, Hanne-Leena, Gröndahl-Yli-Hannuksela, Kirsi, Kristinsson, Karl G., Darenberg, Jessica, Henriques-Normark, Birgitta, Hoffmann, Steen, Caugant, Dominque A., Smith, Andrew J., Lindsay, Diane S. J., Boragine, David M., Palzkill, Timothy
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2020
Soggetti:
Bacteriology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7098749/
https://ncbi.nlm.nih.gov/pubmed/31996443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.01993-19
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