Streptococcus pyogenes pbp2x Mutation Confers Reduced Susceptibility to β-Lactam Antibiotics

Two near-identical clinical Streptococcus pyogenes isolates of emm subtype emm43.4 with a pbp2x missense mutation (T553K) were detected. Minimum inhibitory concentrations (MICs) for ampicillin and amoxicillin were 8-fold higher, and the MIC for cefotaxime was 3-fold higher than for near-isogenic con...

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Detalhes bibliográficos
Publicado no:Clin Infect Dis
Main Authors: Vannice, Kirsten S., Ricaldi, Jessica, Nanduri, Srinivas, Fang, Ferric C., Lynch, John B., Bryson-Cahn, Chloe, Wright, Theodore, Duchin, Jeff, Kay, Meagan, Chochua, Sopio, Van Beneden, Chris A., Beall, Bernard
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7167332/
https://ncbi.nlm.nih.gov/pubmed/31630171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/ciz1000
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