Reduced In Vitro Susceptibility of Streptococcus pyogenes to β-Lactam Antibiotics Associated with Mutations in the pbp2x Gene Is Geographically Widespread

Recently, two related Streptococcus pyogenes strains with reduced susceptibility to ampicillin, amoxicillin, and cefotaxime, antibiotics commonly used to treat S. pyogenes infections, were reported. The two strains had the same nonsynonymous (amino acid-substituting) mutation in the pbp2x gene, enco...

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Bibliografische gegevens
Gepubliceerd in:J Clin Microbiol
Hoofdauteurs: Musser, James M., Beres, Stephen B., Zhu, Luchang, Olsen, Randall J., Vuopio, Jaana, Hyyryläinen, Hanne-Leena, Gröndahl-Yli-Hannuksela, Kirsi, Kristinsson, Karl G., Darenberg, Jessica, Henriques-Normark, Birgitta, Hoffmann, Steen, Caugant, Dominque A., Smith, Andrew J., Lindsay, Diane S. J., Boragine, David M., Palzkill, Timothy
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2020
Onderwerpen:
Bacteriology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7098749/
https://ncbi.nlm.nih.gov/pubmed/31996443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.01993-19
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