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Intermittent Starvation Extends the Functional Lifetime of Primary Human Hepatocyte Cultures

Primary human hepatocyte (PHH) cultures have become indispensable to mitigate the risk of adverse drug reactions in human patients. In contrast to dedifferentiating monocultures, coculture with nonparenchymal cells maintains PHH functions for 2–4 weeks. However, because the functional lifespan of PH...

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Bibliografiska uppgifter
I publikationen:Toxicol Sci
Huvudupphovsmän: Davidson, Matthew D, Khetani, Salman R
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2020
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7098377/
https://ncbi.nlm.nih.gov/pubmed/31977024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfaa003
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