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Intermittent Starvation Extends the Functional Lifetime of Primary Human Hepatocyte Cultures

Primary human hepatocyte (PHH) cultures have become indispensable to mitigate the risk of adverse drug reactions in human patients. In contrast to dedifferentiating monocultures, coculture with nonparenchymal cells maintains PHH functions for 2–4 weeks. However, because the functional lifespan of PH...

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Foilsithe in:Toxicol Sci
Main Authors: Davidson, Matthew D, Khetani, Salman R
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7098377/
https://ncbi.nlm.nih.gov/pubmed/31977024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfaa003
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