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Intermittent Starvation Extends the Functional Lifetime of Primary Human Hepatocyte Cultures
Primary human hepatocyte (PHH) cultures have become indispensable to mitigate the risk of adverse drug reactions in human patients. In contrast to dedifferentiating monocultures, coculture with nonparenchymal cells maintains PHH functions for 2–4 weeks. However, because the functional lifespan of PH...
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| Publicado no: | Toxicol Sci |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7098377/ https://ncbi.nlm.nih.gov/pubmed/31977024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfaa003 |
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