Chargement en cours...

Intermittent Starvation Extends the Functional Lifetime of Primary Human Hepatocyte Cultures

Primary human hepatocyte (PHH) cultures have become indispensable to mitigate the risk of adverse drug reactions in human patients. In contrast to dedifferentiating monocultures, coculture with nonparenchymal cells maintains PHH functions for 2–4 weeks. However, because the functional lifespan of PH...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Toxicol Sci
Auteurs principaux: Davidson, Matthew D, Khetani, Salman R
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7098377/
https://ncbi.nlm.nih.gov/pubmed/31977024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfaa003
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!