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Antibodies that conformationally activate ADAMTS13 allosterically enhance metalloprotease domain function
Plasma ADAMTS13 circulates in a folded conformation that is stabilized by an interaction between the central Spacer domain and the C-terminal CUB (complement components C1r and C1s, sea urchin protein Uegf, and bone morphogenetic protein-1) domains. Binding of ADAMTS13 to the VWF D4(-CK) domains or...
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| Pubblicato in: | Blood Adv |
|---|---|
| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society of Hematology
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7094026/ https://ncbi.nlm.nih.gov/pubmed/32196558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019001375 |
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