Antibodies that conformationally activate ADAMTS13 allosterically enhance metalloprotease domain function

Plasma ADAMTS13 circulates in a folded conformation that is stabilized by an interaction between the central Spacer domain and the C-terminal CUB (complement components C1r and C1s, sea urchin protein Uegf, and bone morphogenetic protein-1) domains. Binding of ADAMTS13 to the VWF D4(-CK) domains or...

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Udgivet i:Blood Adv
Main Authors: Schelpe, An-Sofie, Petri, Anastasis, Roose, Elien, Pareyn, Inge, Deckmyn, Hans, De Meyer, Simon F., Crawley, James T. B., Vanhoorelbeke, Karen
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2020
Fag:
Thrombosis and Hemostasis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7094026/
https://ncbi.nlm.nih.gov/pubmed/32196558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019001375
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