Linker regions and flexibility around the metalloprotease domain account for conformational activation of ADAMTS13

BACKGROUND: Recently, conformational activation of ADAMTS13 was identified. This mechanism showed the evolution from a condensed and inhibited conformation, in which the proximal MDTCS and distal T2-CUB2 domains are in close contact with each other, to an activated structure due to ding with the von...

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Publié dans:J Thromb Haemost
Auteurs principaux: Deforche, L., Roose, E., Vandenbulcke, A., Vandeputte, N., Feys, H.B., Springer, T.A., Mi, L.Z., Muia, J., Sadler, J.E., Soejima, K., Rottensteiner, H., Deckmyn, H., De Meyer, S.F., Vanhoorelbeke, K.
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4778570/
https://ncbi.nlm.nih.gov/pubmed/26391536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.13149
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