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Multi-step binding of ADAMTS13 to VWF
BACKGROUND: ADAMTS13 proteolytic activity is controlled by the conformation of its substrate, von Willebrand factor (VWF), and changes in the secondary structure of VWF are essential for efficient cleavage. Substrate recognition is mediated through several non-catalytic domains in ADAMTS13 distant f...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3863616/ https://ncbi.nlm.nih.gov/pubmed/19765212 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1538-7836.2009.03620.x |
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