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Multi-step binding of ADAMTS13 to VWF
BACKGROUND: ADAMTS13 proteolytic activity is controlled by the conformation of its substrate, von Willebrand factor (VWF), and changes in the secondary structure of VWF are essential for efficient cleavage. Substrate recognition is mediated through several non-catalytic domains in ADAMTS13 distant f...
में बचाया:
| मुख्य लेखकों: | , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2009
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3863616/ https://ncbi.nlm.nih.gov/pubmed/19765212 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1538-7836.2009.03620.x |
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