Generation of Anti-Murine ADAMTS13 Antibodies and Their Application in a Mouse Model for Acquired Thrombotic Thrombocytopenic Purpura

Thrombotic thrombocytopenic purpura (TTP) is a life-threatening thrombotic microangiopathy linked to a deficiency in the metalloprotease ADAMTS13. In the current study, a novel mouse model for acquired TTP was generated to facilitate development and validation of new therapies for this disease. Ther...

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Udgivet i:PLoS One
Main Authors: Deforche, Louis, Tersteeg, Claudia, Roose, Elien, Vandenbulcke, Aline, Vandeputte, Nele, Pareyn, Inge, De Cock, Elien, Rottensteiner, Hanspeter, Deckmyn, Hans, De Meyer, Simon F., Vanhoorelbeke, Karen
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968830/
https://ncbi.nlm.nih.gov/pubmed/27479501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0160388
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