Pathogenicity of Anti-ADAMTS13 Autoantibodies in Acquired Thrombotic Thrombocytopenic Purpura()

BACKGROUND: Acquired thrombotic thrombocytopenic purpura (TTP) is an autoimmune disease in which anti-ADAMTS13 autoantibodies cause severe enzyme deficiency. ADAMTS13 deficiency causes the loss of regulation of von Willebrand factor multimeric size and platelet-tethering function, which results in t...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Thomas, Mari R., de Groot, Rens, Scully, Marie A., Crawley, James T.B.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4563118/
https://ncbi.nlm.nih.gov/pubmed/26425702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2015.06.007
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