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ADAMTS13 Autoantibodies Cloned from Patients with Acquired Thrombotic Thrombocytopenic Purpura: 2. Pathogenicity in an animal model

BACKGROUND: Acquired thrombotic thrombocytopenic purpura (TTP) is a potentially fatal disease in which ultra-large von Willebrand Factor (UL-VWF) multimers accumulate as a result of autoantibody inhibition of the VWF protease, ADAMTS13. Current treatment is not specifically directed at the responsib...

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Detalhes bibliográficos
Publicado no:Transfusion
Main Authors: Ostertag, Eric M., Bdeir, Khalil, Kacir, Stephen, Thiboutot, Michelle, Gulendran, Gayathri, Yunk, Lenka, Hayes, Vincent M., Motto, David G., Poncz, Mortimer, Zheng, X. Long, Cines, Douglas B., Siegel, Don L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4938757/
https://ncbi.nlm.nih.gov/pubmed/27040023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/trf.13583
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