Amiodarone impairs trafficking through late endosomes inducing a Niemann-Pick C-like phenotype

Patients treated with amiodarone accumulate lysobisphosphatidic acid (LBPA), also known as bis(monoacylglycero)phosphate, in airway secretions and develop in different tissues vacuoles and inclusion bodies thought to originate from endosomes. To clarify the origin of these changes, we studied in vit...

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Publicat a:Biochem Pharmacol
Autors principals: Piccoli, Elena, Nadai, Matteo, Caretta, Carla Mucignat, Bergonzini, Valeria, Del Vecchio, Claudia, Ha, Huy Riem, Bigler, Laurent, Dal Zoppo, Daniele, Faggin, Elisabetta, Pettenazzo, Andrea, Orlando, Rocco, Salata, Cristiano, Calistri, Arianna, Palù, Giorgio, Baritussio, Aldo
Format: Artigo
Idioma:Inglês
Publicat: Elsevier Inc. 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7092840/
https://ncbi.nlm.nih.gov/pubmed/21878321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2011.07.090
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