Amiodarone impairs trafficking through late endosomes inducing a Niemann-Pick C-like phenotype

Patients treated with amiodarone accumulate lysobisphosphatidic acid (LBPA), also known as bis(monoacylglycero)phosphate, in airway secretions and develop in different tissues vacuoles and inclusion bodies thought to originate from endosomes. To clarify the origin of these changes, we studied in vit...

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Vydáno v:Biochem Pharmacol
Hlavní autoři: Piccoli, Elena, Nadai, Matteo, Caretta, Carla Mucignat, Bergonzini, Valeria, Del Vecchio, Claudia, Ha, Huy Riem, Bigler, Laurent, Dal Zoppo, Daniele, Faggin, Elisabetta, Pettenazzo, Andrea, Orlando, Rocco, Salata, Cristiano, Calistri, Arianna, Palù, Giorgio, Baritussio, Aldo
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier Inc. 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7092840/
https://ncbi.nlm.nih.gov/pubmed/21878321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2011.07.090
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