Enhanced protective efficacy of H5 subtype influenza vaccine with modification of the multibasic cleavage site of hemagglutinin in retroviral pseudotypes

Traditionally, the multibasic cleavage site (MBCS) of surface protein H5-hemagglutinin (HA) is converted to a monobasic one so as to weaken the virulence of recombinant H5N1 influenza viruses and to produce inactivated and live attenuated vaccines. Whether such modification benefits new candidate va...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Virol Sin
Egile Nagusiak: Tao, Ling, Chen, JianJun, Meng, Jin, Chen, Yao, Li, Hongxia, Liu, Yan, Zheng, Zhenhua, Wang, Hanzhong
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: SP Wuhan Institute of Virology, CAS 2013
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7091038/
https://ncbi.nlm.nih.gov/pubmed/23728771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12250-013-3326-5
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